http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106946722-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-24 |
| filingDate | 2017-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106946722-B |
| titleOfInvention | A kind of deuterium exchange synthesis L-Aspartic acid (3,3-D2) method |
| abstract | The invention discloses a kind of synthesis L-Aspartic acid (3,3-D 2 ) method, its step are as follows: (1) successively L-Aspartic acid or its salt being placed in single port bottle, three times, deuterated hydrochloric acid (or deuterium-oxide+thionyl chloride) then is added under an inert atmosphere in oil pump displacement under inert atmosphere, and temperature rising reflux reacts 1-4 days under inert atmosphere；It (2) will be after the cooling of above-mentioned reaction solution, vacuum distillation recycling deuterated hydrochloric acid, after obtained hydrochloride is dissolved with a small amount of water, filtering with microporous membrane is used again, then pH value is adjusted to 2.5-3.0 with lithium carbonate/lithium hydroxide/triethylamine alcoholic solution, crystallisation by cooling (or anhydrous methanol/dehydrated alcohol that 1-50 times of volume is added) is stood, filtration drying obtains product.The present invention has the advantage that directly adopt cheap amino acid be substrate, and deuterium-oxide is deuterium source, and deuterated hydrochloric acid or thionyl chloride are acid, directly obtains chiral L-Aspartic acid (3,3-D 2 ) sterling. |
| priorityDate | 2017-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.