http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106943378-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5153 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2017-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106943378-B |
| titleOfInvention | Erythrocyte membrane encapsulated polyester arsenic trioxide-loaded nanoparticle and preparation method thereof |
| abstract | The invention discloses a polyester Arsenic Trioxide (ATO) -loaded nanoparticle encapsulated by a erythrocyte membrane and a preparation method thereof, wherein the nanoparticle takes the erythrocyte membrane as a shell and a polyester material as a core; the polyester material is loaded with arsenic trioxide. The prepared nanoparticles have the particle size of about 200nm, round shape, uniform distribution and clear shell-core structure; and has good stability, does not cause hemolysis and agglutination of erythrocytes, and can be used for intravenous injection. Compared with free drugs, the drug delivery system has a remarkable slow release effect, can solve the problem that the blood concentration is rapidly increased after arsenic trioxide is injected into a vein, is beneficial to the circulation of a blood system because substances with the size of 3-400 nm cannot be generally discharged from a kidney or an excretory system, achieves the effect of passive targeting, is beneficial to reducing the blood concentration of toxic drugs, thereby reducing the toxicity, and provides a new strategy for the development of toxic anti-tumor drug preparations. |
| priorityDate | 2017-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.