http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106938996-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 |
| filingDate | 2016-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106938996-B |
| titleOfInvention | A kind of preparation method of Atorvastatin calcium intermediate |
| abstract | The present invention relates to a kind of preparation methods of Atorvastatin calcium intermediate, the preparation method while improving Atorvastatin calcium intermediate yield, the post-processing approach of Atorvastatin calcium intermediate is simple, operating process is simplified, the production cycle shorten, organic solvent consumption reduce, production cost reduce, production operation when risk reduce.Method includes the following steps: 1) react using amine ester and diketone as starting material in the mixed solvent, the mixed solvent is the normal heptane and tetrahydrofuran of volume ratio 1:1-3, every that 5-8ml mixed solvent is added using 1g amine ester；2) 1 gained reaction solution of concentration step removes mixed solvent, obtains Atorvastatin calcium crude intermediate；3) after the dissolution clarification of 1 ethyl alcohol of recrystallisation solvent being added in step 2 products therefrom, 2 purified water of recrystallisation solvent is added, is cooled down, centrifugal drying. |
| priorityDate | 2016-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.