http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106928309-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_91ba5b549cbd7a36dcf03d0bfbad3dc1 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-706 |
| filingDate | 2017-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_187326f3351d886ebe2d95635ddd6307 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_987afc37170b95f7ae81105994713699 |
| publicationDate | 2017-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106928309-A |
| titleOfInvention | A kind of spirosteroid alkane type glycoside alkaloid and its preparation method and application |
| abstract | The present invention provides a spirostanoid alkane-type glycoalkaloid (3β, 22α, 25R)-spironastan-5-enyl-3-O-β-D-glucopyranosyl-(1→2) ‑O‑β‑D‑glucopyranosyl‑(1→4)‑β‑D‑galactopyranoside and its preparation method and application, the spirostanoid alkaloid-type glycoside alkaloid on human lung adenocarcinoma cell A549 , human large cell lung cancer cell H460 and human lung squamous cell carcinoma cell SK-MES-1 all have inhibitory effect, and the half-inhibitory concentration on A549 cells is 61.53 μg/ml, and the half-inhibitory concentration on H460 cells is 159.11 μg/ml. The half-inhibitory concentration of SK-MES-1 cells is 81.64 μg/ml, it can be seen that the (3β, 22α, 25R)-spironalkane-5-enyl-3-O-β-D-pyran prepared by the present invention Glucosyl-(1→2)-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside and preparations thereof can be used for treating non-small cell lung cancer. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111440224-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111171107-A |
| priorityDate | 2017-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.