http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106928224-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-16 |
| filingDate | 2017-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106928224-B |
| titleOfInvention | Indoles Sophoridine derivative and preparation method thereof |
| abstract | The invention discloses indoles Sophoridine derivatives and preparation method thereof, belong to pharmaceutical chemistry and pharmacotherapeutics field.The compound is using Sophoridine as starting material, it hydrolyzes to obtain Chinese scholartree by Sophoridine D cyclic amides key and determines acid potassium salt, esterification occurs with methanol again and obtains the fixed sour methyl esters of Chinese scholartree, the fixed sour methyl esters of Chinese scholartree reacts to obtain intermediate with formaldehyde, and intermediate reacts to obtain the indoles Sophoridine derivative for having stronger anti-tumor activity with indole derivatives.The preparation method of indoles Sophoridine derivative of the present invention, raw material is easy to get, is easy to operate, mild, product yield high of having simplified synthesis step, reaction conditionï¼›It is shown experimentally that indoles Sophoridine derivative of the invention has stronger inhibiting effect to a variety of cancer cell multiplications, such compound is applicable to the treatment of clinically tumour. |
| priorityDate | 2017-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.