http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106928044-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C17-272 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-093 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C63-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-093 |
| filingDate | 2017-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106928044-B |
| titleOfInvention | Preparation method of fluorophenylacetic acid |
| abstract | The invention relates to the field of chemical synthesis, in particular to a preparation method of fluorophenylacetic acid. The invention provides a preparation method of fluorophenylacetic acid, which comprises the following steps: diazotization addition reaction: reacting a compound of formula II in a system containing vinylidene chloride, an acid, a diazo reagent, a phase transfer catalyst and a copper-based catalyst to produce a compound of formula III: and (3) hydrolysis reaction: hydrolyzing the compound of formula III in the presence of an acid to produce the compound of formula I. The preparation method provided by the invention has the advantages of simple and easily obtained raw materials, simple and convenient operation, low raw material cost, mild reaction conditions, low risk, no need of expensive noble metal catalysts and complex industrial operation means, and stable product quality, thereby being suitable for realizing large-scale industrial production. |
| priorityDate | 2017-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 178.