| abstract |
The invention discloses a kind of preparation method of cupric carboxymethyl chitosan sodium alginate support, it is comprised the following steps：(1) ultra-pure water preparation of nano copper solution is used；(2) by carboxymethyl chitosan and nanometer copper solution obtained in sodium alginate addition step (1), it is well mixed, obtains mixed solution；(3) mixed solution for obtaining step (2) is freezed, the initial support after being freezed；(4) to step (3) obtain it is lyophilized after initial support in add CaCl 2 Solution crosslinking, cleaning, the support after being crosslinked；(5) support after the crosslinking for obtaining step (4) is freezed, and obtains final product the cupric carboxymethyl chitosan sodium alginate antibacterial bone repairing support.The cupric carboxymethyl chitosan sodium alginate support that preparation method of the invention is prepared has loose structure, while having good biocompatibility and antibacterial effect. |