| abstract |
The invention discloses treatment cerebral ischemia active site medicine and preparation method based on pepper and Piper longum, the preparation method of the treatment cerebral ischemia active site medicine based on pepper and Piper longum includes：Pepper and Piper longum medicinal material are taken according to mass ratio 1: 1, is extracted using CO 2 supercritical equipment after crushing；The remaining dregs of a decoction add multi-function extractor, plus 10 times of alcohol refluxs of amount 70% to extract 3 times after extracting；After extract solution is filtered concentrate, plus 3 times amount dichloromethane extract 3 times, be condensed into after liquid extract with Rotary Evaporators be put into air dry oven dry both active site.Present invention reduces pepper and the Piper longum composition excitant of itself, there is different degrees of improvement to the nervous function symptom of permanent cerebral ischemia rat, as a result fully confirm that prepared active component toxicity is relatively low and with good neuroprotection. |