http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106905357-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-081 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-083 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-10 |
| filingDate | 2017-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106905357-B |
| titleOfInvention | A kind of preparation method of Silthiopham key intermediate |
| abstract | The invention discloses a kind of preparation methods of Silthiopham key intermediate, including, trimethyl silicon substrate propiolic acid, thionyl chloride and allyl amine are taken, molar ratio is 1:1.5:1~1:2:1；Trimethyl silicon substrate propiolic acid is dissolved in solvent, and catalyst is added dropwise；Under ice bath, thionyl chloride is added dropwise；At 0~25 DEG C, stirring；Allyl amine is added dropwise in distillation, gained residue under ice bath, reacts；Extraction, it is dry, obtain trimethyl silicon substrate propioloyl allyl amine；Wherein, catalyst is 1:100~5:100 with trimethyl silicon substrate propiolic acid molar ratio；Wherein, solvent is one of toluene, methylene chloride, diethoxymethane or a variety of；Wherein, catalyst is one of n,N-Dimethylformamide, hexamethylphosphoramide or a variety of.The method of the present invention, raw material and reaction process are simple and environmentally-friendly, safe.Reaction time is short, and target product yield is high, reduces production cost, and Atom economy is good, meets the theory of Green Chemistry, has very big competitive advantage and industrial production utility value. |
| priorityDate | 2017-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.