| abstract |
The present invention provides a kind of preparation method of substituted benzenesulfonylmatrine butane hydrochloride, the method comprises that matrine MT is subjected to ring-opening reaction, carboxyl protection and condensation reaction of R-substituted benzenesulfonyl chloride, reduction reaction, Hydroxyl protection and removal reaction; this preparation method shortens the two-step reaction compared with the prior art, and the total yield of the reaction is about 45%, which is more than 20% higher than the total yield of the method disclosed in the prior art, and after refining treatment , the purity of the compound is as high as 98% or more; and no column chromatography is required in the preparation process, which is more suitable for industrial production. |