http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106905317-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 |
| filingDate | 2017-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106905317-B |
| titleOfInvention | 4-Substituted Sampangine alkaloid derivatives and their synthetic methods and applications |
| abstract | The invention discloses a 4-substituted sampangine alkaloid derivative and a synthesis method and application thereof. The derivative has the structure shown in the following formula (I), and its synthesis method is as follows: take the Sampangine alkaloid with the structure shown in the formula (II) and place it in the first organic solvent to react with pyridine perbromide to obtain the formula (III) 4-bromo substituted Sampangine alkaloid of structure shown in ), then react with sodium methylate in the second organic solvent to obtain the 4-methoxyl group of structure shown in formula (IV) to replace Sampangine alkaloid, then with formula (V) The diamine of the shown structure is reacted in the third organic solvent to obtain the corresponding crude product of the target compound; the compounds of the structures shown by the formula (I) to the formula (V) are respectively as follows: Wherein, in formula (I) and formula (V), n=2 to 3, and R 2 is -N(CH 3 ) 3 , -NEt 2 , -OH, or |
| priorityDate | 2017-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 146.