http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106905305-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-12 |
| filingDate | 2017-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106905305-B |
| titleOfInvention | Preparation method of engelizin |
| abstract | The invention discloses a preparation method of engelizin, which comprises the following steps: 1) carrying out Grignard exchange reaction on the compound 5, and then reacting with a glucolactone derivative 6 to obtain a compound 7; wherein X is bromine or iodine, LG is chlorine, bromine, mesyloxy or p-toluenesulfonyloxy, PG is acetyl, tert-butyryl or benzoyl; 2) deprotecting the compound 7 under the action of alkali to obtain a final product of the compound of formula 8 of empagliflozin; the preparation route is simple to operate, reaction steps are shortened, the yield is high, the purity of the obtained product is high, and the preparation method is suitable for large-scale production. |
| priorityDate | 2017-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 129.