| abstract |
The invention discloses a method for resolving chiral amine compounds and an intermediate thereof. The present invention provides a method for separating a chiral amine compound and an intermediate thereof. The method for separating comprises the following steps: in a solvent, the chiral amine compound is subjected to a salt-forming reaction with a resolving agent, and that is enough; The chiral amine compound refers to 3-(1-aminoethyl)phenol, (2R,3S)-4-amino-1,2,3-cyclopentatriol or trans-cyclohexanediamine; the The resolving agent is L-α-amino acid, L-α-amino acid derivative, D-α-amino acid or D-α-amino acid derivative; the method can preferably resolve the chiral amine compound, and the method receives High efficiency and low cost, suitable for industrial production. |