| abstract |
The invention discloses a kind of method of carbonyl Iron cluster collaboration trace palladium chtalyst Sonogashira coupling reactions, this method using palladium bichloride, tri-iron dodecacarbonyl as catalyst, acetylenic ketone is part, methanol is solvent, makes halogenated aryl hydrocarbon, Terminal Acetylenes, K 2 CO 3 Reaction, obtains aryl acetylene compound；This method considerably reduces the dosage of palladium metal, and operation is simple, and mild condition (generally 60 DEG C or so), functional group compatibility is good, and high income, catalyst amount is low, and yield is high. |