http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106902112-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-415 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 |
| filingDate | 2017-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106902112-B |
| titleOfInvention | Application of the IMB-A6 as androgen receptor antagonists |
| abstract | The present invention relates to drug leads fields, specifically disclose IMB-A6 in the application of application and IMB-A6 in preparation treatment androgen disorders and male contraception drug in terms of as androgen receptor antagonists.The present invention is by constructing reliable androgenic activity screening technique, multiple drug leads are tested to the inhibiting effect of estrogen receptor activity, finally discovery IMB-A6 is a kind of novel androgen receptor antagonists, can inhibit the activity of wild type and mutability androgen receptor.Further, the present invention tests the activity of the anti-prostate cancer of IMB-A6, it was found that IMB-A6 has preferable activity for the prostate gland cancer cell such as LNCaP of the AR positive, it is then inactive to the prostate gland cancer cell of AR feminine gender, and its expression activity that can inhibit androgen receptor, it is similar to the miscellaneous Shandong amine of positive drug grace. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109432097-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109432097-A |
| priorityDate | 2017-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 113.