http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106902098-B

Outgoing Links

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filingDate 2017-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2020-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2020-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-106902098-B
titleOfInvention Anti-tumor implant film and preparation method thereof
abstract The invention discloses an anti-tumor implant membrane and a preparation method thereof, wherein the anti-tumor implant membrane is an electrospun nanofiber membrane loaded with oncolytic viruses, and the preparation method comprises the following steps: step one, preparing an electrospinning film consisting of nano fibers from a biodegradable high polymer material with amino groups by using an electrostatic spinning technology; and step two, soaking the electrospun nanofiber membrane obtained in the step one into an oncolytic virus solution, and enriching oncolytic viruses on the fiber membrane through electrostatic adsorption to obtain the anti-tumor implant membrane. Aiming at the problems of local chemotherapy, drug resistance and the like after tumor operation and the technical limitation of intratumoral injection when the oncolytic virus is applied, the invention is directly implanted into a tumor resection part to locally treat residual tumor, avoid tumor recurrence and widen the application range of the oncolytic virus. The implant film is made of biodegradable high polymer materials, has good biocompatibility, can be completely absorbed by a human body, can physically isolate a tumor excision part from peritoneum, and plays a role in preventing adhesion.
priorityDate 2017-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Total number of triples: 32.