http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106890332-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 |
| filingDate | 2017-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106890332-B |
| titleOfInvention | Thermo-sensitive gold nanocage hydrogel drug delivery system with photothermal chemotherapy precise and synergetic anti-tumor effect |
| abstract | The invention discloses a preparation method of a thermo-sensitive gold nanocage hydrogel drug delivery system with accurate synergic anti-tumor effect in photothermal chemotherapy, which comprises the following steps: 1) mixing the gold nanocages with the high-temperature ligand, stirring, incubating, and centrifuging to obtain the gold nanocages modified by the high-temperature ligand; wherein the high-temperature ligand is a chain temperature-sensitive polymer containing a disulfide bond, and the phase transition temperature of the high-temperature ligand is 39-50 ℃; 2) dispersing the high-temperature ligand-modified gold nanocages obtained in the step 1) in an ammonium sulfate solution, stirring, centrifuging, dispersing the solid in an adriamycin aqueous solution, and standing in a dark place to obtain drug-loaded gold nanocages; 3) mixing the drug-loaded gold nanocages obtained in the step 2) with a low-temperature ligand, stirring, incubating, and centrifuging to obtain a thermo-sensitive gold nanocage hydrogel drug-loaded system with accurate synergetic anti-tumor effect in photothermal chemotherapy; wherein the low-temperature ligand is a chain temperature-sensitive polymer containing a disulfide bond, and the phase transition temperature of the low-temperature ligand is 26-35 ℃. |
| priorityDate | 2016-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.