| abstract |
The invention discloses a kind of one group of methylated genes and its detection method, one group of methylated genes are p16, DLEC1, CDH1, DAPK and RUNX3 gene, and DNA gene orders are respectively：SEQ ID NO：1、SEQ ID NO：2、SEQ ID NO：3、SEQ ID NO：4、SEQ ID NO：5, in lung cancer patient plasma DNA sample, there is high methylation in the specific CpG sites of said gene.These genes of the invention are lung cancer biomarkers；Can be used as the basis of design pulmonary cancer diagnosis reagent, it is adaptable to the early stage auxiliary detection of hospital's lung cancer, early stage risk assessment can be done to High Risk of Lung Cancer crowd. |