| abstract |
The invention discloses a synthesis method of amikacin. The synthesis method is as follows: firstly prepare the partially silylated protected product of kanamycin A; then dehydrate it with PHBA under the action of DCC to obtain the acylated product; the acylated product is purified by hydrolysis, nitrilation reaction and column chromatography Amika star. The synthesis method of the present invention no longer uses NOP, removes the esterification synthesis active ester step reported in the existing patent, and greatly reduces the damage to the health of employees; and the solid waste generated in the production process can be greatly reduced, and the product yield is increased, which is very Suitable for industrial production. |