http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106866743-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-185 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F15-0033 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F15-0053 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6486 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-555 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 |
| filingDate | 2017-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106866743-B |
| titleOfInvention | Tumor-targeting metal complex and synthetic method and application |
| abstract | The invention discloses a kind of tumor-targeting metal complex and synthetic method and applications.Its synthetic method is：Ligand with substituent group is coordinated by connecting the molecule with targeting, ligand with metal ion, and tumor-targeting metal complex is synthesized；The ligand is one kind in phenanthroline derivative, dipyridyl derivatives, benzimidazoles derivative, phenylpyridine analog derivative and thiophene pyridine derivatives；The molecule with targeting is one kind in biotin, folic acid, integrin, transferrins, cell-penetrating peptide, eight poly arginines, 1 membrane albumen of MUC, galactosamine, new vessels targeting peptides and granular leukocyte macrophage stimulus factor；The metal ion is ruthenium, osmium, rhodium or iridium ion.The complex that method through the invention obtains can be absorbed by tumor cells selectivity, and induce its apoptosis.In nude mice lotus knurl model, tumor-targeting complex can reduce the side effect to organ-tissue to the imaging and treatment of tumour. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112266402-A |
| priorityDate | 2017-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 233.