| abstract |
The invention discloses a method for synthesizing 3-aminomethyltetrahydrofuran. The method comprises: 1. 1,4-butenediol undergoes condensation and cyclization reaction under the action of a fixed acid catalyst to generate 2,5-dihydrofuran ; Two, 2,5 dihydrofuran under the effect of homogeneous catalyst HRhCO[P(PhX) 3 ] 3 , carry out hydroformylation reaction to obtain 3-formaldehyde tetrahydrofuran; Three, 3-formaldehyde tetrahydrofuran is reacted with hydroxylamine compounds , to obtain 3-methoximetetrahydrofuran; four, carry out hydrogenation reaction with 3-methoximetetrahydrofuran under the action of a catalyst to obtain 3-aminomethyltetrahydrofuran. The synthesis method of the present invention has simple process, short steps, high overall yield, environmental protection, and low cost. The product yield in each step is greater than 90%, and the overall yield of the finally prepared 3-aminomethyltetrahydrofuran is The rate is greater than 80%. |