| abstract |
The invention belongs to the field of biomedicine, and in particular relates to a 1,3,4-selenodiazole compound with pharmaceutical activity. Since there are not many types of selenium heterocyclic rings, based on the strong tumor growth inhibitory function of BPTES (thiadiazole compounds), we synthesized selenium diazole compounds with various functional groups substituted by a new synthetic method, and passed the test It has been confirmed that these compounds have the functions of tumor inhibition, anti-oxidation and cell protection; Selenadiazole can be replaced as the bioelectronic isostere of thiadiazole; At present, many drugs contain thiadiazole, so there are many synthesis bands Seleniadiazole derivatives with a functional group can further optimize the activity of medicinal thiadiazole compounds, which will be of great significance in the development and application of new drugs. |