http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106866543-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-18 |
| filingDate | 2017-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106866543-B |
| titleOfInvention | A method of benzimidazole compound is catalyzed and synthesized under microwave radiation in water phase |
| abstract | The present invention discloses a kind of method that benzimidazole compound is catalyzed and synthesized under the microwave radiation in water phase, its step are as follows: the metal chloride, proline lithium and substitution 2- halogenated aniline substrate of catalytic amount being added in the reaction vessel, ammonium hydroxide, benzaldehyde derivative, inorganic base and water are placed in microwave reaction instrument under certain temperature, power and react, after a certain period of time, it is concentrated under reduced pressure, product obtains benzimidazole compound by column chromatographic purifying；Metal chloride is iron chloride, cobalt chloride, nickel chloride or copper chloride in above-mentioned steps.Inorganic base is sodium hydroxide, cesium carbonate, sodium carbonate, potassium hydroxide or potassium phosphate in above-mentioned steps.Reaction temperature in above-mentioned steps in microwave reaction instrument is 20-200 DEG C.The present invention is that one kind is environmental-friendly, easy to operate, and safety is cheap, efficiently prepares the method for benzimidazole compound.Compared with prior art, the method reaction condition is mild, easy to operate, yield is high, safety, low in cost, environmental protection. |
| priorityDate | 2017-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 117.