http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106860915-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/D01D5-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/D01D5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-56 |
| filingDate | 2017-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106860915-B |
| titleOfInvention | A kind of mineralized collagen biomimetic bone repair material modified by hyaluronic acid oligosaccharide and its preparation method |
| abstract | The invention relates to a mineralized collagen bionic bone repair material modified by hyaluronic acid oligosaccharide and a preparation method thereof. Hyaluronic acid oligosaccharide-modified mineralized collagen biomimetic bone repair material, the structure is as follows: the collagen in the collagen-hydroxyapatite composite material connects hyaluronic acid oligosaccharides through C-N bonds to obtain glycosylated mineralized collagen Composite material, the molecular weight of hyaluronic acid oligosaccharide is 776-5000Da. The present invention uses the Schiff base reaction to modify collagen with hyaluronic acid oligosaccharides for the first time to obtain covalently bonded glycosylated collagen, and proposes to use glycosylated collagen as a mineralization template for bone scaffold design for the first time. In addition to the functions of promoting cell migration, proliferation, differentiation and wound healing, low molecular weight HA provides a new material basis and research strategy for the construction of vascularized scaffolds in vitro. |
| priorityDate | 2017-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.