| abstract |
The present invention provides a kind of arginine-modified chitosan, its preparation method and injectable antibacterial hydrogel, and described injectable antibacterial hydrogel is made of arginine-modified chitosan having the structure of formula (I) and a cross-linking agent in a solvent for self-cross-linking reaction; Compared with the prior art, the injectable antibacterial hydrogel provided by the present invention has antibacterial properties and good biocompatibility, can be formed in situ in the body, and is conducive to directly acting on the lesion and exerting it for a long time medicinal effect; and the polyoxyethylene glycol with terminal aldehyde has an aldehyde structure, which can replace the commonly used formaldehyde, glutaraldehyde and other cross-linking agents that are more toxic to the human body; at the same time, the injectable antibacterial hydrogel also has Good biodegradability, can be degraded in the body, and the degradation products are amino acids, polysaccharides, polyethylene glycol, which can be directly excreted from the body through the kidneys, and are harmless to the human body. |