http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106832003-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0821 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06147 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 |
| filingDate | 2017-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106832003-B |
| titleOfInvention | Acid-sensitive polypeptide and application thereof |
| abstract | The invention discloses an acid-sensitive polypeptide and application thereof, wherein the acid-sensitive polypeptide is formed by connecting a peptide chain with reversibly changed net charges to cell-penetrating peptide through a flexible peptide chain. The acid-sensitive polypeptide can selectively exert acid sensitivity, and restore electropositivity at an acid environment part to realize efficient cell uptake. Connecting the acid-sensitive polypeptide to an amphiphilic block copolymer to synthesize an acid-sensitive polypeptide modified amphiphilic block copolymer; then, a mixed micelle of the amphiphilic block copolymer and an acid-sensitive polypeptide modified amphiphilic block copolymer micelle are prepared by a film dispersion method, and the obtained micelle shows the targeting property which is easy to be compatible with the part of an acidic microenvironment (such as a tumor, an inflammation or an infection part, an intracellular endosome or lysosome internal environment and the like), thereby having important significance for targeted therapy. |
| priorityDate | 2017-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 169.