http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106831997-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5169 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5123 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-775 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-28 |
| filingDate | 2015-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106831997-B |
| titleOfInvention | Polypeptide, lipoprotein-like nanoparticles and their applications |
| abstract | The invention discloses a polypeptide, a lipoprotein-like nanoparticle (LNP) and an application thereof. The LNP comprises at least one phospholipid and at least one of the polypeptides. The polypeptide is a helix-loop-helix structure polypeptide, which comprises at least two amphipathic α-helices, and the two amphipathic α-helices are connected by at least one linking peptide comprising a loop structure. The present invention can promote the stable formation of lipid nanoparticles with uniform size and smaller particle size by trapping the helical part of the polypeptide into the surface layer of the lipoprotein-like nanoparticle, and at the same time, by making the ring sequence protrude from the surface of the lipoprotein-like nanoparticle , and also facilitates the insertion of functional sequences, thereby realizing the multifunctionalization of LNPs. The use of LNP to encapsulate hydrophobic functional substances can further expand its use, for example, it can be used as a drug-loading system. The drug-loading system has the characteristics of low toxicity, high stability, and easy functionalization. And cell, tissue imaging provides a simple and effective means. |
| priorityDate | 2015-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 146.