http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106831975-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate | 2017-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106831975-B |
| titleOfInvention | Application of heat shock transcription factor 1 in regulation and control of expression of 15kDa selenoprotein |
| abstract | The invention discloses application of a heat shock transcription factor 1 in regulation and control of expression of 15kDa selenoprotein. The application provided by the invention is specifically the application of the heat shock transcription factor 1 in any one of the following applications: (a1) promoting expression of Sep15 protein in target cells; (a2) promoting transcription of the Sep15 gene in target cells; (a3) the Sep15 promoter activity was enhanced in the target cells. The invention finds that the transcription factor HSF1 can be combined with a Sep15 promoter, regulates the Sep15 gene transcription and promotes the Sep15 protein expression. In the case of heat shock and fever in physiological state, the transcription factor HSF1 can start Sep15 transcription, increase Sep15 expression, thereby participating in the physiological process, helping the protein fold correctly or helping the protein unfold and deliver to other proteins to help the protein fold correctly. Under endoplasmic reticulum stress, HSF1 can also promote Sep15 expression, thereby participating in endoplasmic reticulum protein control and further promoting cell survival. The invention has important significance for preventing and/or treating diseases related to endoplasmic reticulum stress. |
| priorityDate | 2017-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 461.