http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106831809-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-22 |
| filingDate | 2015-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106831809-B |
| titleOfInvention | A method of it is extracted from fermentation liquid and purifies mibemycin |
| abstract | The method that the invention discloses a kind of to extract from fermentation liquid and purify mibemycin.First by the flocculation of mibemycin fermentation liquid, filtering, mycelia slag is obtained；Mycelia slag is extracted with water-insoluble solvent, extract liquor successively carries out pickling, concentration, alkali process, then carries out reextraction；Then the upper silica gel column chromatography of filtrate is filtered to take in pickling, cryoprecipitation；Stripping liquid carries out derivation process, and secondary silica gel column chromatography crystallizes, and mibemycin derivative is arrived in separation；By derivative hydrolysis, extraction, concentration, crystallization, drying, the mibemycin that mibemycin A3 and A4 content is greater than 80% is obtained.Requirement of this method to production equipment is lower, and mild condition is simple to operation, and the mibemycin purity is high of acquisition, is suitable for carrying out large-scale production, economic benefit is obvious. |
| priorityDate | 2015-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.