http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106831742-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 |
| filingDate | 2016-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106831742-B |
| titleOfInvention | A kind of preparation method of iloperidone intermediate |
| abstract | The present invention relates to a kind of preparation method of iloperidone intermediate, described method, the steps are as follows: (1) potassium hydroxide is added in methanol, add (2,4-difluorophenyl)-(4-piperidone Pyridyl) ketone oxime hydrochloride; (2) heating, temperature control 50-60 ℃ reaction 2-3h; (3) cooling to room temperature, adding anhydrous MgSO 4 , stirring for 0.8-1.2h, suction filtration, the filtrate reduced Concentrate under reduced pressure; (4) Add acetone, stir at room temperature for 0.4-0.6h, filter, add saturated methanolic HCl solution dropwise to the filtrate with stirring to make pH = 2-3, filter with suction, and dry to obtain a white solid. Wherein, the water content of methanol is less than 0.5%. |
| priorityDate | 2016-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.