http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106831664-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-08 |
| filingDate | 2017-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106831664-B |
| titleOfInvention | A kind of preparation method of bearing taxanes and its intermediate |
| abstract | The present invention provides the preparation methods of a kind of bearing taxanes and its intermediate, a kind of preparation method of TPI-287 intermediate A, the present invention starts with from the initial step of raw material 10- deacetylation baccatin III (also known as 10-DAB), the position the C-7 hydroxyl of 10-DAB is protected first, then it is selectively oxidized reaction, TPI-287 intermediate A is obtained, good basis is provided for subsequent step, solves the problems such as low intermediate yield and purification difficult, preparation method reaction step provided by the invention is relatively simple, reaction condition is controllable, reaction raw materials are cheap and easy to get, and yield with higher, it is suitble to scale mass production.Key intermediate of the TPI-287 intermediate A prepared by the present invention as synthesis TPI-287 can be further used for the potential anticancer drug TPI-287 that preparation has anticancer activity. |
| priorityDate | 2017-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 86.