http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106831648-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-24 |
| filingDate | 2016-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106831648-B |
| titleOfInvention | The synthetic method of diazoxiide |
| abstract | A kind of (I) synthetic method of diazoxiide, include the following steps: the chloro- 2- nitrobenzene sulfonamide (II) of (a) 5- in solvent A, with Raney Ni (Raney Nickel) catalytic hydrogen reduction, obtain the chloro- 2- aminobenzene sulfonamide (III) of 5-, wherein, the temperature of reduction reaction is 20 ~ 40 DEG C, and the pressure of reduction reaction is 3 ~ 10kg/cm 2 , the time of reduction reaction is 3 ~ 5 hours；(b) the chloro- 2- aminobenzene sulfonamide (III) of 5- is in the presence of inorganic matter acid binding agent; acetylation is carried out with acylating reagent in solvent B; product row cyclization reaction in higher boiling atent solvent C; obtain diazoxiide (I) crude product; wherein, the temperature of acetylization reaction is 0 ~ 30 DEG C, and the time of acetylization reaction is 2 ~ 10 hours; the temperature of cyclization reaction is 240 ~ 250 DEG C, and the time of cyclization reaction is 0.5 ~ 1.5 hour；(c) diazoxiide (I) crude product is refined through 80% ethyl alcohol, obtains diazoxiide (I) finished product. |
| priorityDate | 2016-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 116.