http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106831639-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-48 |
| filingDate | 2016-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106831639-B |
| titleOfInvention | The preparation method of Cefcapene side-chain acid |
| abstract | The present invention relates to a kind of preparation methods of Cefcapene side-chain acid, belong to medicine intermediate technical field.The preparation method is that ketene dimer is added into alcohol organic solvent under nitrogen protection, then bromine is added dropwise to be reacted, the mixed liquor quenching reaction of methylene chloride and water is added, separate organic phase, acetic acid is added into organic phase, propionic aldehyde is added dropwise simultaneously after cooling and organic alkali catalyst A is reacted, then thiocarbamide is added to be reacted, it is concentrated through vacuum distillation, methylene chloride is added into concentrate, di-tert-butyl dicarbonate and organic alkali catalyst B are reacted, then liquid alkaline is added to be reacted, hydrochloric acid is added dropwise after cooling and carries out crystallization, through filtering, isopropanol water solution elution, (Z) -2- (2- t-butoxycarbonyl amino thiazole-4-yl) -2- penetenoic acid is obtained after drying, that is Cefcapene side-chain acid.The present invention is using ketene dimer as starting material, and side reaction is few, high income, and obtained product purity is high, and reaction condition is mild, is more easy to realize industrial production. |
| priorityDate | 2016-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.