http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106831602-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 |
| filingDate | 2016-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106831602-B |
| titleOfInvention | Preparation method and application of silver-mediated 4-substituted-2-amino-5-fluoropyrimidine compounds |
| abstract | The present invention relates to a preparation method and application of a 4-substituted-2-amino-5-fluoropyrimidine compound. The structural formula of the compound is: Wherein, R is selected from aryl, styryl or anilyl. The 4-substituted-2-amino-5-fluoropyrimidine compound is in an organic solvent, with a 4-substituted-2-aminopyrimidine compound as a substrate, silver carbonate as an additive, and Selectfluor as a fluorine source to control the reaction The temperature is 70°C, reacted for 2 hours, and then separated and purified to prepare it. Compared with the prior art, the present invention realizes the direct fluorination of 2-aminopyrimidine compounds for the first time, and has the advantages of short reaction time, mild conditions, wide application range of substrates, regioselective fluorination and the like. The prepared 4-substituted-2-amino-5-fluoropyrimidine compound can be used as an intermediate for the preparation of medicines. |
| priorityDate | 2016-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 72.