| abstract |
The invention belongs to the technical field of medicine, and relates to a (N-1,2,3,4-tetrahydroisoquinolyl)-ferulamide compound, a preparation method and an application thereof, the structure of which is shown in formula I, . The (N-1,2,3,4-tetrahydroisoquinolinyl)-ferulamide compound of the present invention has good butyrylcholinesterase inhibitory activity and significant inhibition of Aβ 1-42 aggregation in vitro experiments activity, antioxidant activity and better neuroprotective activity against hydrogen peroxide-induced PC12 cell injury, indicating that the compound (N‑1,2,3,4‑tetrahydroisoquinolinyl)‑ferulamide (I) It is a multi-target inhibitor, which has further shown a better effect on the treatment of Alzheimer's disease in vivo experiments, and has low toxicity, and has a good clinical application prospect. |