http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106831538-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-56 |
| filingDate | 2017-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106831538-B |
| titleOfInvention | The preparation method of tropsch imatinib intermediate |
| abstract | The present invention relates to a kind of preparation methods that tropsch imatinib intermediate is new, more particularly to tropsch imatinib intermediate (3R, 4R) -1- benzyl-N, the preparation method of 4- lupetidine -3- amine dihydrochloride, with 1- benzyl -4- methyl-1, 2, 3, 6- tetrahydropyridine is as starting material, by one-step method by olefin oxidation at ketone II, after forming imines III with amine later, amine is formed with asymmetric reduction imines, cis-structure IV is obtained by recrystallization removal transisomer, finally final product (3R is obtained with chiral resolution, 4R) -1- benzyl-N, 4- lupetidine -3- amine dihydrochloride I.The process innovation of this preparation method, shortens processing step, greatly improves asymmetric compound synthesis yield, takes a firm foundation for industrialized production. |
| priorityDate | 2017-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.