http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106831384-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-513 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-513 |
| filingDate | 2017-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106831384-B |
| titleOfInvention | Cadinane sesquiterpene compound and preparation method and application thereof |
| abstract | The invention provides a cadinane sesquiterpene compound and a preparation method and application thereof, and the preparation method comprises the following steps: (1) preparing a Fissistigma Oldhamii extract: cold soaking or hot extracting dry stems of Fissistigma Oldhamii with 30-95% v/v ethanol to obtain extractive solution, and concentrating under reduced pressure to obtain unguent; (2) separation and purification: diluting the Fissistigma Oldhamii extract with water to obtain suspension, sequentially extracting with petroleum ether and ethyl acetate, concentrating the ethyl acetate extractive solution under reduced pressure to obtain extract, and separating by column chromatography, thin layer chromatography, molecular sieve chromatography and high performance liquid chromatography. The invention also discloses a preparation method of the compound and application of the compound in preparing a medicament for resisting rheumatoid arthritis. The invention discovers the activity of the cadinane sesquiterpene compound in the inhibition of the proliferation of rheumatoid arthritis synovial cells for the first time, and the cadinane sesquiterpene compound can be used for preparing the anti-rheumatoid arthritis medicine. |
| priorityDate | 2017-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.