http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106800650-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-33313 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-333 |
| filingDate | 2015-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106800650-B |
| titleOfInvention | Functional targeting carrier material distearoylphosphatidylethanolamine-polyethylene glycol-phenylglucoside and its preparation method and application |
| abstract | The invention discloses a functional targeting carrier material distearoyl phosphatidylethanolamine-polyethylene glycol-phenylglucoside and a preparation method and application thereof. In the present invention, the DSPE-PEG 2000 -GLU compound is modified on the surface of the drug-loaded liposome as a targeting molecule, so that the drug can effectively pass through the blood-brain barrier, selectively accumulate in tumor cells, and produce a targeting effect. For example, the uptake ratio of C6 glioma cells and glioma stem cells to the drug in a low-glucose environment is significantly increased, so that the drug has a stronger growth inhibitory effect on glioma cells, making the drug show stronger The effect of crossing the blood-brain barrier and killing brain glioma stem cells, that is, dual targeting, can prolong the circulation time of the drug in ICR mice and the degree of aggregation in tumor tissue, thereby prolonging the survival period of the organism. |
| priorityDate | 2015-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.