Predicate |
Object |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-515 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-107 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-468 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
filingDate |
2016-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate |
2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CN-106800599-B |
titleOfInvention |
Anti-human EGFR and Notch multispecific antibody, preparation method and application thereof |
abstract |
The invention belongs to the technical field of biological medicines, and discloses an anti-human EGFR and Notch multispecific antibody C-T Crossmab which can be combined with EGFR, Notch2 and Notch 3. The C-T Crossmab of the invention comprises two heavy chain polypeptides and two light chain polypeptides, the invention also provides a nucleotide sequence for coding the heavy chain polypeptides, a recombinant expression vector comprising the nucleotide sequence, and a transformed host cell. The multispecific antibodies of the present invention are useful in the treatment of neoplastic disease. |
priorityDate |
2016-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |