abstract |
The present invention relates to a disubstituted aryl compound and its application. The structure of the disubstituted aryl compound is shown in formula I, II or III. Through experimental verification, it is found that the disubstituted aryl compound can be combined with azole The joint use of antifungal drugs can increase the sensitivity of drug-resistant bacteria to azole drugs and realize the reversal of drug resistance. Therefore, the present invention provides a new approach for the treatment of clinical drug-resistant fungi. |