abstract |
The present invention relates to novel aminopyridyloxypyrazole compounds that inhibit the activity of transforming growth factor beta receptor 1 (TGFβR1), pharmaceutical compositions comprising said compounds and use of said compounds for the treatment of cancer, preferably colon cancer, black A method for melanoma, hepatocellular carcinoma, renal carcinoma, glioblastoma, pancreatic cancer, myelodysplastic syndrome, lung and gastric cancer and/or fibrosis, preferably liver fibrosis and chronic kidney disease. |