| abstract |
The present invention provides compounds of formula (I) and pharmaceutically acceptable compositions thereof. Compounds of formula (I) were found to bind bromodomain and/or bromodomain-containing proteins (eg, bromo and extra terminal (BET) proteins). Also provided are methods for inhibiting the activity (e.g., increased activity) of a bromodomain and/or bromodomain-containing protein and for treating and/or preventing bromodomain or bromodomain-containing protein in a subject Methods, uses and kits of compounds and pharmaceutical compositions related to diseases such as proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, neurological diseases, metabolic diseases, endocrine diseases and radiation poisoning. The compounds, pharmaceutical compositions and kits are also useful for male contraception. |