http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106754661-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-235 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-09 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-061 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-074 |
| filingDate | 2016-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106754661-B |
| titleOfInvention | A technical method for differentiating skin stem cells into sperm through ectopic development |
| abstract | The invention relates to a method for inducing skin stem cells to differentiate into sperm. First, mouse skin stem cells are co-cultured with fibroblasts treated with mitomycin C to induce them to differentiate into PGCs, and then the PGC cell mixture is passed through a receptor. The mouse efferent tubule was injected retrogradely into the seminiferous tubules of the testis; the testis of the recipient mouse was developed for one month, and the testis of the recipient mouse was taken out. HE staining analysis showed that spermatogenesis was restored in the seminiferous tubules, and cells with typical sperm morphology appeared, and The spermatogenic cells in seminiferous tubules that restore spermatogenesis express GFP and MVH, etc. The method of the invention has little harm to the body and no ethical problems, can effectively induce the skin stem cells to differentiate into sperm cells, has high differentiation efficiency, and the differentiated sperm cells have typical sperm morphology and express sperm cell-specific genes at the same time. |
| priorityDate | 2016-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 124.