http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106750047-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5138 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F4-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F290-062 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F290-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F222-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F222-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F4-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 |
| filingDate | 2016-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106750047-B |
| titleOfInvention | Preparation method of pH-responsive adriamycin nano-drug capsule with positive surface charge |
| abstract | The invention relates to a preparation method of a pH-responsive adriamycin nano-drug capsule with positive surface charges, which comprises the steps of uniformly mixing adriamycin nano-drug particles with acrylate groups modified on the surfaces with a certain amount of neutral monomer Acrylamide (AM), positively charged monomer N- [3- (dimethylamino) propyl ] methacrylamide (DMAPMA) and a pH-responsive degradation cross-linking agent in deionized water, adding a redox initiator ammonium persulfate/Tetramethylethylenediamine (TEMED) to initiate in-situ free radical polymerization, and dialyzing, freezing and drying to obtain the adriamycin nano-drug capsule. By changing the type of the cross-linking agent, adjusting the dosage of the monomer and the cross-linking agent and the like, the adriamycin nano-drug capsule with smaller average particle size, uniform dispersion, higher dissolution rate, larger dissolution rate and the like and better performance can be obtained. The method provides a new idea and selection, is simple to operate, and can realize the precise control of the structure and the surface of the adriamycin nano capsule and the efficient delivery in vivo. |
| priorityDate | 2016-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.