http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106749316-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 2016-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106749316-B |
| titleOfInvention | A kind of azepine penthienate [2,3-d] pyrimidone -3- carboxamides derivatives and purposes |
| abstract | The present invention relates to a kind of azepine penthienate [2,3- d ] pyrimidone -3- carboxamides derivatives and purposes.The compound is using 2- butanone as raw material, 4 reacted under the action of triethylamine with cyan-acetic ester and sulphur powder, 5- dimethyl -2- amino-thenoic acid ethyl ester 1, then under the action of phosphorus oxychloride, obtain azacyclo- pyrantel ketone compounds 2-4, azepine penthienate [2,3- is obtained under the action of the concentrated sulfuric acid and concentrated nitric acid again d ] pyrimidone -3- carboxylic acid compounds 5-7, then with azepine penthienate [2,3- d ] pyrimidone -3- carboxylic acid compounds be parent nucleus, react to obtain 24 kinds of azepine penthienate [2,3- respectively with aromatic amine, fatty amine and aminopyridine d ] pyrimidone -3- Carbox amide 5a-5e, 6a-6k and 7a-7h, through to melanogenesis amount and antibacterial activity, as the result is shown: gained compound has facilitation to the generation of melanocyte；Compound 5b, 6e, 6f, 6g and 6k have inhibiting effect to Candida albicans；Compound 5b, 6f, 6k and 7d also show inhibiting effect to staphylococcus aureus. |
| priorityDate | 2016-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 128.