http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106749248-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_324efbd59cda6faf7813ccb0626896ec |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-18 |
| filingDate | 2016-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c30d4204eac45e1ccce908ae67fff46c |
| publicationDate | 2017-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106749248-A |
| titleOfInvention | A kind of preparation method of antiviral drug of Entecavir |
| abstract | The invention discloses a kind of preparation method of antiviral drug of Entecavir, the preparation method is comprised the following steps：Step one：There is the compound that ring-closure reaction obtains shown in formula E in the presence of peroxidized t-butyl perbenzoate, sodium carbonate and R 1,1 ' join 2 naphthols in compound shown in formula D；Step 2：Compound shown in formula E and the generation mitsunobu reactions of the chloropurine of 2 amino 6 are obtained the compound shown in formula F；Step 3：The reaction that is hydrolyzed in acidic aqueous solution of compound shown in formula F is obtained into Entecavir；And the preparation method of the compound shown in formula D.The present invention effectively reduces reactions steps; overall yield is greatly improved; the compound intermediate yield shown in compound intermediate and formula E particularly shown in formula A is substantially high; ketal protection hydroxyl is easier deprotection; the yield of Entecavir is further ensured; the method mild condition, is adapted to industrialized production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112625041-A |
| priorityDate | 2016-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.