| abstract |
The present invention relates to the terpenoid and its preparation method and application in a kind of Roots of Euphorbia soongarica, this method with Roots of Euphorbia soongarica ( E.soongarica ) herb be raw material, it is extracted with organic solvent, pass through solvent extraction, normal-phase silica gel column chromatography method, reversed-phase silica gel column chromatography method, three kinds to four kinds methods in Sephadex LH-20 gel filtration chromatography method are separated, obtain 10 new terpenoids (including 5 Diterpenes, 3 carbon drop triterpenes and 2 triterpene compounds), and multi-medicine tolerant reversal activity measurement has been carried out to 10 new terpenoids are obtained, the result shows that: the new terpenoid has different degrees of multi-medicine tolerant reversal activity, it can be used for preparing the application in multi-drug resistance reversing medicaments, or it is prepared into antineoplastic combined medicament with antitumor combination. |