| abstract |
The present invention relates to a kind of Bola type ribavirin compound, the structure is as shown in general formula I, by researching the characteristic of this special structure of Bola type amphiphile molecule, to 1,2,4-ribavirin ribavirin The structure of Wellin is optimized to improve its water solubility and inhibition rate of cancer cell growth. Furthermore, this type of compound has the ability to self-assemble in aqueous solution to form nanoscale particles, which also makes it easier to gather in tumor tissues to achieve targeted drug delivery due to the high permeability and retention effect of solid tumors. It can encapsulate other small molecule drugs to achieve the effect of combined drug. In the general formula, n, R 1 , R 2 , R 3 and R 4 are as defined in the claims. |