| abstract |
The invention discloses a preparation method of a Buvaracetam intermediate shown in B-VI, comprising the following steps: dissolving B-IV and R-phenethylamine in a solvent, crystallizing, filtering, and recrystallizing to obtain B ‑V, which converts to B‑VI. In the preparation process of the present invention, no chiral chromatographic column is needed to separate the isomers, and only simple steps such as extraction, washing, drying, and concentration can be used to separate the effective components. The separation process is simple, and the production cost of brivaracetam is greatly reduced. |