http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106748851-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 |
| filingDate | 2016-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106748851-B |
| titleOfInvention | Ge Lienai and levocarnitine coupling compound (I) and preparation method thereof |
| abstract | The present invention provides a kind of Mitiglinides and levocarnitine coupling compound (I) and preparation method thereof, a certain proportion of Mitiglinide is added in the preparation method into organic solvent first and levocarnitine is sufficiently mixed to form suspension, and a certain proportion of catalyst is added into suspension to carry out esterification coupling reaction；Suction filtration obtains filter cake；After filter cake uses organic solvent washing, recrystallization reagent is added to be recrystallized, to which Mitiglinide and levocarnitine coupling compound (I) be prepared.The present invention by animal experiments show that, the Mitiglinide realizes the purpose for cooperateing with the pharmacological activity for playing Mitiglinide and levocarnitine with levocarnitine coupling compound (I), can either reducing blood glucose realize the generation of effectively inhibition diabetic retinopathy again. |
| priorityDate | 2016-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.